Tamakoshi Koji, Yatsuya Hiroshi, Wada Keiko, Matsushita Kunihiro, Otsuka Rei, Yang Pei Ou, Sugiura Kaichiro, Hotta Yo, Mitsuhashi Hirotsugu, Kondo Takaaki, Toyoshima Hideaki
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, Japan.
Circ J. 2006 Mar;70(3):262-7. doi: 10.1253/circj.70.262.
Low birth weight has been associated with adult hypertension in several Western populations. This association needs to be evaluated in Japanese people.
A population-based cross-sectional study of 3,107 subjects (2,303 males and 804 females) aged 35-66 years was conducted. The participants responded to a questionnaire about their birth weights, blood pressure, medical history, parental history, and lifestyle factors. Hypertension was defined as systolic blood pressure > or =140 mmHg and/or diastolic blood pressure > or =90 mmHg and/or under treatment by anti-hypertensives. Multiple logistic regression analysis adjusted for age, sex, body mass index, parental history, and lifestyle revealed the adjusted odds ratios for hypertension were 1.26 (95% confidence interval: 0.88-1.80), 1.00 (reference), 0.89 (0.73-1.08) and 0.70 (0.49-1.00) in subjects in birth weight categories of <2,500 g, 2,500-<3,000 g, 3,000-<3,500 g, 3,500- g, respectively (p-value for trend =0.009). Furthermore, this inverse association was clearly pronounced in normal-weight subjects.
Low birth weight was independently associated with adult hypertension in the Japanese workplace population. Our results support the inverse association observed previously in Western populations and suggest that intrauterine environmental insults might lead to permanent changes in the metabolism and structure of the fetal organs influencing the regulation of blood pressure.
在一些西方人群中，低出生体重与成人高血压有关。这种关联需要在日本人中进行评估。
对3107名年龄在35 - 66岁的受试者（2303名男性和804名女性）进行了一项基于人群的横断面研究。参与者回答了一份关于他们出生体重、血压、病史、家族病史和生活方式因素的问卷。高血压定义为收缩压≥140 mmHg和/或舒张压≥90 mmHg和/或正在接受抗高血压治疗。对年龄、性别、体重指数、家族病史和生活方式进行调整后的多因素logistic回归分析显示，出生体重类别<2500 g、2500 - <3000 g、3000 - <3500 g、3500 - g的受试者患高血压的调整后比值比分别为1.26（95%置信区间：0.88 - 1.80）、1.00（参照）、0.89（0.73 - 1.08）和0.70（0.49 - 1.00）（趋势p值 = 0.009）。此外，这种负相关在正常体重受试者中明显更为显著。
在日本职场人群中，低出生体重与成人高血压独立相关。我们的结果支持了先前在西方人群中观察到的负相关，并表明子宫内环境损伤可能导致胎儿器官代谢和结构的永久性变化，从而影响血压调节。
