Wright Clinton B, Sacco Ralph L, Rundek Tatjana R, Delman Joshua B, Rabbani LeRoy E, Elkind Mitchell S V
J Stroke Cerebrovasc Dis. 2006 Jan-Feb;15(1):34-8. doi: 10.1016/j.jstrokecerebrovasdis.2005.08.009.
Inflammation has been linked to cognitive decline and dementia but the mechanism is not clear and few studies have included Hispanic and black subjects that may be at increased risk of these disorders.
We performed a cross-sectional analysis of the association between inflammatory marker levels and cognition in the stroke-free population-based cohort of the Northern Manhattan Study. Mini Mental State Exam (MMSE) scores were the continuous outcome and we adjusted for sociodemographic and vascular risk factors as well as subclinical atherosclerosis.
Of the inflammatory markers, only interleukin (IL)-6 levels were associated with the MMSE. In univariate analysis age, hypertension, diabetes, smoking, moderate alcohol use, total homocysteine, carotid intima media thickness, and body mass index were positively associated with IL-6 levels. Hispanics compared to whites, those with less than a high school education, hypertension, cardiac disease, and total homocysteine were associated with lower MMSE scores. In a multivariate linear regression model, IL-6 was negatively associated with MMSE score adjusting for sociodemographic and vascular risk factors.
IL-6 levels were negatively associated with performance on the MMSE in this multiethnic cohort. Adjusting for vascular disease and subclinical atherosclerosis did not attenuate the association, suggesting a direct effect on the brain.
炎症与认知功能衰退及痴呆有关，但机制尚不清楚，且很少有研究纳入可能患这些疾病风险增加的西班牙裔和黑人受试者。
我们对北曼哈顿研究中无卒中的基于人群队列的炎症标志物水平与认知之间的关联进行了横断面分析。简易精神状态检查表（MMSE）评分是连续结果，我们对社会人口统计学和血管危险因素以及亚临床动脉粥样硬化进行了校正。
在炎症标志物中，只有白细胞介素（IL）-6水平与MMSE相关。在单因素分析中，年龄、高血压、糖尿病、吸烟、适度饮酒、总同型半胱氨酸、颈动脉内膜中层厚度和体重指数与IL-6水平呈正相关。与白人相比，西班牙裔、高中以下学历者、高血压患者、心脏病患者和总同型半胱氨酸水平与较低的MMSE评分相关。在多变量线性回归模型中，在校正社会人口统计学和血管危险因素后，IL-6与MMSE评分呈负相关。
在这个多民族队列中，IL-6水平与MMSE表现呈负相关。校正血管疾病和亚临床动脉粥样硬化并没有减弱这种关联，提示对大脑有直接影响。
