Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Neuroepidemiology. 2011;37(3-4):153-9. doi: 10.1159/000332208. Epub 2011 Oct 15.
The metabolic syndrome (MetS) is a risk factor for diabetes, stroke, myocardial infarction, and increased mortality, and has been associated with cognition in some populations. We hypothesized that MetS would be associated with lower Mini-Mental State Examination (MMSE) scores in a multi-ethnic population, and that MetS is a better predictor of cognition than its individual components or diabetes.
We conducted a cross-sectional analysis among 3,150 stroke-free participants. MetS was defined by the modified National Cholesterol Education Program guidelines-Adult Treatment Panel III (NCEP-ATPIII) criteria. Linear regression and polytomous logistic regression estimated the association between MMSE score and MetS, its individual components, diabetes, and inflammatory biomarkers.
MetS was inversely associated with MMSE score (unadjusted β = -0.67; 95% CI -0.92, -0.41). Adjusting for potential confounders, MetS was associated with lower MMSE score (adjusted β = -0.24; 95% CI -0.47, -0.01), but its individual components and diabetes were not. Those with MetS were more likely to have an MMSE score of <18 than a score of ≥ 24 (adjusted OR = 1.94; 95% CI 1.26, 3.01). There was an interaction between MetS and race-ethnicity, such that MetS was associated with lower MMSE score among non-Hispanic whites and Hispanics but not non-Hispanic blacks.
MetS was associated with lower cognition in a multi-ethnic population. Further studies of the effect of MetS on cognition are warranted, and should account for demographic differences.
代谢综合征（MetS）是糖尿病、中风、心肌梗死和死亡率增加的危险因素，并且与某些人群的认知功能有关。我们假设，代谢综合征与多种族人群的简易精神状态检查（MMSE）评分较低有关，并且代谢综合征比其单个成分或糖尿病更能预测认知功能。
我们对 3150 名无中风的参与者进行了横断面分析。代谢综合征采用改良的国家胆固醇教育计划指南-成人治疗小组 III（NCEP-ATPIII）标准定义。线性回归和多项逻辑回归估计了 MMSE 评分与代谢综合征、其单个成分、糖尿病和炎症生物标志物之间的关联。
代谢综合征与 MMSE 评分呈负相关（未调整的β=-0.67；95%置信区间-0.92，-0.41）。调整潜在混杂因素后，代谢综合征与 MMSE 评分较低相关（调整后的β=-0.24；95%置信区间-0.47，-0.01），但其单个成分和糖尿病则没有。患有代谢综合征的人比 MMSE 评分≥24 的人更有可能得分<18（调整后的比值比=1.94；95%置信区间 1.26，3.01）。代谢综合征与种族-民族之间存在交互作用，即代谢综合征与非西班牙裔白人和西班牙裔人群的 MMSE 评分较低有关，但与非西班牙裔黑人无关。
代谢综合征与多种族人群的认知功能较低有关。需要进一步研究代谢综合征对认知功能的影响，并应考虑人口统计学差异。
