Zhongyin Zhou, Hesheng Luo, Jun Liu, Jihong Chen
Department of Gastroenterology, Renmin Hospital, Wuhan University, HuBei, Peoples Republic of China.
Saudi Med J. 2006 Feb;27(2):161-4.
To investigate the relationship of serum lipids and apolipoprotein (apoE) gene polymorphism to colorectal adenomas.
This study took place in the Department of Gastroenterology, Renmin Hospital of Wuhan University, PR China from June 2003 to March 2005. Ninety-eight patients with colorectal adenomas and 40 healthy subjects were enrolled, and their serum levels of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were determined. The apoE gene polymorphism was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Serum TC levels of colorectal adenomas group (5.32 +/- 0.85 mmol/L), distal colorectal adenomas group (5.58 +/- 0.63 mmol/L), and villous adenoma group (5.49 +/- 0.69 mmol/L) were higher than the control group (4.28 +/- 0.62 mmol/L, p=0.016), proximal colorectal adenomas group (4.82 +/- 0.58 mmol/L, p=0.038) and non-villous adenoma group (4.76 +/- 0.58 mmol/L, p=0.03). Serum HDL-C levels of colorectal adenomas group (1.39 +/- 0.25 mmol/L) were lower than the control group (1.51 +/- 0.29 mmol/L) (p=0.035). Serum lipids levels of each genotype in colorectal adenomas group were not statistically significant. Apolipoprotein E3/E4 genotypic frequency in colorectal adenomas group (7.1%) was lower than the control group (17.5%) (p=0.012).
The findings suggest that altered lipid metabolism may be differentially associated with colorectal adenomas and the persons with apoE E3/E4 genotype have lower risk suffering from colorectal adenomas than those with other genotypes.
探讨血脂和载脂蛋白（apoE）基因多态性与大肠腺瘤的关系。
本研究于2003年6月至2005年3月在武汉大学人民医院消化内科进行。纳入98例大肠腺瘤患者和40例健康受试者，测定其血清甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法鉴定apoE基因多态性。
大肠腺瘤组（5.32±0.85 mmol/L）、远端大肠腺瘤组（5.58±0.63 mmol/L）和绒毛状腺瘤组（5.49±0.69 mmol/L）的血清TC水平高于对照组（4.28±0.62 mmol/L，p = 0.016）、近端大肠腺瘤组（4.82±0.58 mmol/L，p = 0.038）和非绒毛状腺瘤组（4.76±0.58 mmol/L，p = 0.03）。大肠腺瘤组的血清HDL-C水平（1.39±0.25 mmol/L）低于对照组（1.51±0.29 mmol/L）（p = 0.035）。大肠腺瘤组各基因型的血脂水平无统计学意义。大肠腺瘤组载脂蛋白E3/E4基因型频率（7.1%）低于对照组（17.5%）（p = 0.012）。
研究结果表明，脂质代谢改变可能与大肠腺瘤存在差异关联，apoE E3/E4基因型个体患大肠腺瘤的风险低于其他基因型个体。
