结直肠癌：从肿瘤发生到治疗
Colorectal carcinoma: from tumorigenesis to treatment.
作者信息
Wang W S, Chen P M, Su Y
机构信息
Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
出版信息
Cell Mol Life Sci. 2006 Mar;63(6):663-71. doi: 10.1007/s00018-005-5425-4.
Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately, owing to rapid expansion of knowledge and technology development in oncology, much progress has been made regarding the diagnosis, understanding of the molecular genetics and malignant progression, as well as the novel regimens of CRC. In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin beta-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis. Current treatments as well as several potentially applicable therapeutic strategies for CRC are also discussed.
结直肠癌（CRC）是一种复杂且往往致命的遗传性疾病。幸运的是，由于肿瘤学领域知识的迅速扩展和技术的发展，在结直肠癌的诊断、分子遗传学和恶性进展的理解以及新治疗方案方面已经取得了很大进展。在这篇综述中，我们总结了结直肠癌的分期系统、最关键的基因和表观遗传改变、基质金属蛋白酶-7（MMP-7）的多效性作用、刺猬信号通路的争议性作用、胸腺素β-4的有趣参与以及假定的结肠（癌）干细胞在结直肠癌肿瘤发生中的可能作用。还讨论了结直肠癌的当前治疗方法以及几种潜在适用的治疗策略。
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