Soltanian Ali Reza, Hosseini Bistoon, Mahjub Hossein, Bahreini Fatemeh, Nazemalhosseini Mojarad Ehsan, Ghaffari Mohammad Ebrahim
Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
Modeling of Noncommunicable Diseases Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Cell J. 2021 Aug;23(3):313-318. doi: 10.22074/cellj.2021.7295. Epub 2021 Jul 17.
Colorectal cancer (CRC) is the fourth most common and the second most lethal cancer worldwide. CRC mortality is increasing in Iran. In the current study, we aimed to investigate association between rs11614913 polymorphism of the gene and CRC.
In this case-control study, we assessed association of the rs11614913 polymorphism in 194 patients with CRC (case) and 286 healthy individuals (control). The expectation-maximization (EM) algorithm method was used to adjust deviation from Hardy-Weinberg equilibrium (HWE).
There was no significant difference between genotypic frequencies of rs11614913 polymorphism in the control and case groups. Genotypic frequencies differed in the adjusted and unadjusted deviations from the HWE. Analysis of unadjusted and adjusted independent variables showed that age, sex, alcohol consumption, and drug use were statistically significant.
Our findings showed that rs11614913 polymorphism was not associated with CRC risk. Deviation from HWE affected the results. It is recommended to perform further studies to establish HWE. Ignoring the equilibrium can cause in consistencies in the results of studies.
结直肠癌（CRC）是全球第四大常见癌症，也是第二大致命癌症。伊朗的结直肠癌死亡率正在上升。在本研究中，我们旨在调查该基因的rs11614913多态性与结直肠癌之间的关联。
在这项病例对照研究中，我们评估了194例结直肠癌患者（病例组）和286名健康个体（对照组）中rs11614913多态性的关联。采用期望最大化（EM）算法方法来调整偏离哈迪-温伯格平衡（HWE）的偏差。
对照组和病例组中rs11614913多态性的基因型频率没有显著差异。在调整和未调整的偏离HWE的情况下，基因型频率有所不同。对未调整和调整后的自变量进行分析表明，年龄、性别、饮酒和药物使用具有统计学意义。
我们的研究结果表明，rs11614913多态性与结直肠癌风险无关。偏离HWE影响了结果。建议进行进一步研究以建立HWE。忽略平衡可能会导致研究结果不一致。
