Chen Wei, Luo Rong-cheng, Fan Wei-wen, Ma Shu-dong
Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2006 Feb;26(2):227-8, 230.
To study the clinical value of combined detection of 4 tumor markers, namely lactic dehydrogenate (LDH), tissue polypeptide specific antigen (TPS), carcinoembryonic antigen (CEA) and beta2-microglobulin (beta2-MG) in patients with non-Hodgkin's lymphoma (NHL).
The serum level of LDH was determined with automatic biochemical analyzer and TPS, CEA and beta2-MG levels were determined by enzyme-linked immumosorbent assay (ELISA) in 59 patients with NHL and 40 healthy adults.
The levels of the 4 tumor markers were significantly higher in NHL patients than in the healthy control subjects (P<0.05). After chemotherapy, the serum levels of TPS and beta2-MG were significantly lowered in the patients who showed favorable response to the treatment (P<0.05), but the levels of LDH and CEA showed no significant change (P>0.05). The serum levels of LDH, TPS, CEA and beta2-MG in the patients in a stable or progressive phase did had no significant changes after chemotherapy (P>0.05).
Combined detection of LDH, TPS, CEA and beta2-MG can be helpful to assist diagnosis of NHL and treatment evaluation.
研究联合检测乳酸脱氢酶（LDH）、组织多肽特异性抗原（TPS）、癌胚抗原（CEA）和β2-微球蛋白（β2-MG）这4种肿瘤标志物在非霍奇金淋巴瘤（NHL）患者中的临床价值。
采用自动生化分析仪检测59例NHL患者及40例健康成年人血清中的LDH水平，采用酶联免疫吸附测定法（ELISA）检测TPS、CEA和β2-MG水平。
NHL患者的4种肿瘤标志物水平显著高于健康对照者（P<0.05）。化疗后，治疗反应良好的患者血清中TPS和β2-MG水平显著降低（P<0.05），但LDH和CEA水平无显著变化（P>0.05）。处于稳定期或进展期的患者化疗后血清中LDH、TPS、CEA和β2-MG水平无显著变化（P>0.05）。
联合检测LDH、TPS、CEA和β2-MG有助于NHL的辅助诊断及治疗评估。
