Zheng Lu, Zheng Jian, Zhao Yuying, Wang Bin, Wu Lijun, Liang Hong
School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, People's Republic of China.
Bioorg Med Chem Lett. 2006 May 15;16(10):2765-8. doi: 10.1016/j.bmcl.2006.02.009. Epub 2006 Feb 28.
Three new triterpenoid saponins, julibroside J(29) (1), julibroside J(30) (2), and julibroside J(31) (3), were isolated from the stem bark of Albizia julibrissin Durazz. (Leguminosae) by using chromatographic method. Their structures were established by spectroscopic methods. Compounds 1, 2, and 3 displayed significant anti-tumor activities in vitro against PC-3M-1E8, HeLa, and MDA-MB-435 cancer cell lines at 10microM assayed by SRB and MTT methods.
采用色谱法从合欢(豆科)的茎皮中分离出三种新的三萜皂苷,分别为朱利布罗皂苷J(29)(1)、朱利布罗皂苷J(30)(2)和朱利布罗皂苷J(31)(3)。通过光谱方法确定了它们的结构。采用SRB和MTT法在10微摩尔浓度下检测发现,化合物1、2和3在体外对PC-3M-1E8、HeLa和MDA-MB-435癌细胞系具有显著的抗肿瘤活性。