来自中国合欢的细胞毒性齐墩果烷三萜皂苷。

Cytotoxic oleanane triterpene saponins from Albizia chinensis.

作者信息

Liu Rui, Ma Shuanggang, Yu Shishan, Pei Yuehu, Zhang Sen, Chen Xiaoguang, Zhang Jianjun

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

出版信息

J Nat Prod. 2009 Apr;72(4):632-9. doi: 10.1021/np800576s.

DOI:10.1021/np800576s

PMID:19256478

Abstract

Three new oleanane-type triterpene saponins, albizosides A-C (1-3), were isolated from the stem bark of Albizia chinensis. Their structures were established by 1D and 2D NMR experiments and chemical methods. Compounds 1-3 showed cytotoxic activity against a small panel of human tumor cell lines as well as hemolytic activity against rabbit erythrocytes.

摘要

从中国合欢的茎皮中分离出三种新的齐墩果烷型三萜皂苷，即合欢皂苷A - C（1 - 3）。通过一维和二维核磁共振实验以及化学方法确定了它们的结构。化合物1 - 3对一小部分人类肿瘤细胞系显示出细胞毒性活性，并且对兔红细胞具有溶血活性。