合欢中的两种新细胞毒三萜皂苷 Albizosides D 和 E。
Albizosides D and E, two new cytotoxic triterpene saponins from Albizia chinensis.
机构信息
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
出版信息
Carbohydr Res. 2010 Sep 3;345(13):1877-81. doi: 10.1016/j.carres.2010.05.024. Epub 2010 May 31.
PMID:20655038
Abstract
Two oleanane-type triterpene saponins, named albizosides D and E (1 and 2), together with a known compound, Julibroside J(8) (3), were isolated from the stem bark of Albizia chinensis. The structures of compounds 1 and 2 were established by 1D, 2D NMR experiments, and chemical methods, and they showed moderate cytotoxic activity against a small panel of human tumor cell lines.
摘要
从合欢 Albizia chinensis 的茎皮中分离得到两种齐墩果烷型三萜皂苷，分别命名为 Albizioside D 和 E（1 和 2），以及一种已知化合物 Julibroside J（8）（3）。通过 1D、2D NMR 实验和化学方法确定了化合物 1 和 2 的结构，它们对一组小的人类肿瘤细胞系表现出中等的细胞毒性活性。
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