Pietrzak B, Cyganek A, Jabiry-Zieniewicz Z, Bobrowska K, Durlik M, Paczek L, Kamiński P
First Department of Obstetrics and Gynecology, Warsaw Medical University, Pl. Starynkiewicza 1/3, 02-015 Warsaw, Poland.
Transplant Proc. 2006 Jan-Feb;38(1):180-3. doi: 10.1016/j.transproceed.2005.12.045.
One of the effects of an improved general health state after successful kidney transplantation in women of reproductive age is recurrence of regular menstrual function.
Sixty-three ovarian cycles in female kidney transplant recipient, aged from 18 to 44 years, at 1.5 to 15 years after transplantation, were compared with 50 cycles of healthy women. We monitored the menstrual cycle duration as well as follicle stimulation hormone (FSH), leutinizing hormone (LH), estradiol, progesterone, prolactin, creatinine, and testosterone serum concentrations as well as hematocrit and obtained sonographic observations of ovarian follicle growth and ovulation.
Of the recipients, 68.1% had regular menstrual cycles. Ovulatory cycles were observed in 45% of patients. Estradiol concentration established in the first phase of the cycle was significantly higher among the transplanted group (mean value 226.86 +/- 97.45 pg/mL vs 140.00 +/- 61.00 in the controls). A significantly lower level of progesterone (15.05 +/- 17.34 ng/mL vs 30.79 +/- 18.48 ng/mL in the controls) and of testosterone were observed in kidney recipients. Other hormonal parameters did not differ significantly between the groups.
Similar serum FSH, LH, and prolactin concentrations as well as increased levels of estrogens were observed in kidney transplant recipients compared with healthy nonrecipients. The rate of ovulatory cycles in regularly menstruated kidney graft recipients was similar to that of healthy women. Stabilization of graft function resulted in restoration of normal ovarian hormone metabolism and ovulatory cycles in female kidney transplanted recipients.
育龄期女性肾移植成功后，整体健康状况改善的一个表现是月经功能恢复正常。
对63例年龄在18至44岁之间、移植后1.5至15年的女性肾移植受者的卵巢周期，与50例健康女性的周期进行比较。我们监测了月经周期时长以及血清卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇、孕酮、催乳素、肌酐和睾酮的浓度，以及血细胞比容，并对卵巢卵泡生长和排卵进行了超声观察。
68.1%的受者月经周期规律。45%的患者观察到有排卵周期。移植组在月经周期第一阶段的雌二醇浓度显著更高（平均值226.86±97.45 pg/mL，而对照组为140.00±61.00）。肾移植受者的孕酮水平（15.05±17.34 ng/mL，而对照组为30.79±18.48 ng/mL）和睾酮水平显著更低。两组之间其他激素参数无显著差异。
与健康未接受移植者相比，肾移植受者血清FSH、LH和催乳素浓度相似，但雌激素水平升高。月经规律的肾移植受者的排卵周期率与健康女性相似。移植肾功能稳定导致女性肾移植受者卵巢激素代谢和排卵周期恢复正常。
