Suppr超能文献

肝移植术后围绝经期女性的月经周期和性激素谱

Menstrual cycle and sex hormone profile in perimenopausal women after liver transplantation.

作者信息

Jabiry-Zienjewicz Z, Kaminski P, Bobrowska K, Pietrzak B, Wielgos M, Zieniewicz K, Krawczyk M

机构信息

1st Department of Obstetrics and Gynecology, The Medical University of Warsaw, Warsaw, Poland.

出版信息

Transplant Proc. 2006 Nov;38(9):2909-12. doi: 10.1016/j.transproceed.2006.08.114.

Abstract

UNLABELLED

Excellent long-term outcomes of transplant patients let many female liver-recipients experience perimenopausal problems. This study assessed menstrual patterns and sex hormone profiles in women of perimenopausal age who experienced end-stage liver failure treated by transplantation (OLT).

MATERIALS AND METHODS

Menstrual patterns, sex hormone profiles, and biochemical parameters of liver function were analyzed before and after OLT in 13 liver-transplanted patients of perimenopausal age. Nineteen healthy perimenopausal women served as controls.

RESULTS

The most common abnormality of the menstrual cycle observed in the study group was secondary amenorrhea, which affected six liver-transplanted women. Three months after OLT amenorrhea was still observed in six patients, regular menstrual cycles in six and irregular bleeding in one graft recipient. One year after transplantation regular menstruations were noted in four, irregular bleeding in four, and secondary amenorrhea in five liver-transplanted women. Similar levels of follicle stimulating hormone, luteinizing hormone, prolactin, progesterone and testosterone as well as lower levels of estradiol and DHEA-sulfate were observed in patients with liver failure, both before and after grafting, compared with healthy women. After OLT E2 levels increased from 32.05 +/- 18.04 to 49.12 +/- 22.21.

CONCLUSIONS

One year after OLT disturbances in menstrual patterns affect most (69%) perimenopausal female liver recipients. Both before and after OLT significantly lower levels of estradiol and DHEA-S were observed in transplanted patients compared with healthy controls. Hormonal therapy of amenorrhea or irregular menstruations may be required in that group of patients.

摘要

未标注

移植患者出色的长期预后使许多女性肝移植受者经历围绝经期问题。本研究评估了接受肝移植(OLT)治疗的围绝经期终末期肝衰竭女性的月经模式和性激素谱。

材料与方法

分析了13例围绝经期肝移植患者OLT前后的月经模式、性激素谱和肝功能生化指标。19名健康围绝经期女性作为对照。

结果

研究组观察到的最常见月经周期异常是继发性闭经,影响了6名肝移植女性。OLT后3个月,仍有6例患者闭经,6例月经周期规律,1例移植受者有不规则出血。移植后1年,4例肝移植女性月经规律,4例不规则出血,5例继发性闭经。与健康女性相比,肝衰竭患者在移植前后的促卵泡生成素、促黄体生成素、催乳素、孕酮和睾酮水平相似,而雌二醇和硫酸脱氢表雄酮水平较低。OLT后,E2水平从32.05±18.04升高至49.12±22.21。

结论

OLT后1年,月经模式紊乱影响了大多数(69%)围绝经期女性肝移植受者。与健康对照组相比,移植患者在OLT前后的雌二醇和硫酸脱氢表雄酮水平均显著降低。该组患者可能需要进行闭经或月经不调的激素治疗。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验