下颌囊肿摘除术后的骨再生：组织工程骨与髂骨自体移植物的比较
Bone regeneration after enucleation of mandibular cysts: comparing autogenous grafts from tissue-engineered bone and iliac bone.
作者信息
Pradel Winnie, Eckelt Uwe, Lauer Günter
机构信息
Department of Oral and Maxillofacial Surgery, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Germany.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):285-90. doi: 10.1016/j.tripleo.2005.06.001. Epub 2006 Jan 19.
OBJECTIVE
The aim of this study was to compare bone regeneration after grafting enucleated mandibular cyst cavities using either autogenous osteoblasts cultured on a biomaterial or autogenous spongiose iliac bone.
STUDY DESIGN
Twenty patients with 22 mandibular cysts were assessed. Eleven cysts were filled in with tissue-engineered bone (autogenous osteblasts cultured on demineralized bone matrix Osteovit) and 11 with spongiose iliac bone as controls. Panoramic radiographs were taken preoperatively, immediately postoperatively, and 3, 6, and 12 months after surgery. Radiolucency was computer analyzed using gray-level histograms.
RESULTS
In both groups bone regeneration took place in a similar fashion. After 3 and 6 months there were few differences in bone density between the groups. However, in radiographic controls after 12 months ossification was considerably stronger in cysts grafted with tissue-engineered bone.
CONCLUSION
These results advocate for the clinical application of tissue-engineered bone as an alternative viable filling material for cysts.
目的
本研究旨在比较使用生物材料培养的自体成骨细胞或自体松质髂骨移植摘除下颌囊肿腔后的骨再生情况。
研究设计
对20例患有22个下颌囊肿的患者进行评估。11个囊肿填充组织工程骨（在脱矿骨基质Osteovit上培养的自体成骨细胞），11个填充松质髂骨作为对照。术前、术后即刻以及术后3、6和12个月拍摄全景X线片。使用灰度直方图对透光度进行计算机分析。
结果
两组骨再生方式相似。3个月和6个月后，两组骨密度差异不大。然而，12个月后的影像学对照显示，移植组织工程骨的囊肿骨化明显更强。
结论
这些结果支持组织工程骨作为囊肿替代可行填充材料的临床应用。
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