使用干细胞进行口腔内骨再生——临床医生需要了解的内容：基于15年的MEDLINE检索
Intraoral Bone Regeneration Using Stem Cells-What a Clinician Needs to Know: Based on a 15-Year MEDLINE Search.
作者信息
Jain Vanshika, Sybil Deborah, Premchandani Shubhangi, Krishna Meenakshi, Singh Sanjay
机构信息
Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, New Delhi, India.
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.
出版信息
Front Dent. 2021 Nov 14;18:40. doi: 10.18502/fid.v18i40.7774. eCollection 2021.
The choice of an appropriate autogenous source of stem cells has not been adequately addressed especially for intraoral bone regeneration. The current review aims to assess the clinical success of various human stem cells in oral bone regeneration. Articles studying the potential of various stem cells utilized for reconstruction of intraoral bone defects in humans were included in this review. Relevant articles were electronically searched in MEDLINE-PubMed database using keywords with different combinations. Only the articles published in English between 2006 and 2020 were included in this review. It was concluded that intra and extraoral stem cells can be successfully used for bone regeneration of various jaw defects. Depending on the origin, quantity, and quality, each cell type has its own advantages and disadvantages. Also, it brings to the fore the need for more clinical studies to validate and adopt the use of stem cells in regular clinical practice.
特别是对于口腔内骨再生，尚未充分解决合适的自体干细胞来源的选择问题。本综述旨在评估各种人类干细胞在口腔骨再生中的临床成功率。本综述纳入了研究各种干细胞用于人类口腔内骨缺损重建潜力的文章。使用不同组合的关键词在MEDLINE-PubMed数据库中进行电子检索相关文章。本综述仅纳入了2006年至2020年期间以英文发表的文章。得出的结论是，口腔内和口腔外干细胞均可成功用于各种颌骨缺损的骨再生。根据来源、数量和质量，每种细胞类型都有其自身的优缺点。此外，这凸显了需要更多临床研究来验证并在常规临床实践中采用干细胞的使用。
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