自体骨应用于颗粒状无机牛骨材料后在体内促进新生骨形成。
Acceleration of de novo bone formation following application of autogenous bone to particulated anorganic bovine material in vivo.
作者信息
Thorwarth Michael, Schlegel Karl Andreas, Wehrhan Falk, Srour Safwan, Schultze-Mosgau Stefan
机构信息
Department of Oral and Maxillofacial Surgery/Plastic Surgery, University of Jena, Jena, Germany.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar;101(3):309-16. doi: 10.1016/j.tripleo.2005.04.024. Epub 2005 Sep 26.
OBJECTIVE
This prospective animal study examined the de novo bone formation following application of deproteinized bovine bone matrix (DBBM) with or without autogenous bone (AB) to osseous defects.
STUDY DESIGN
Defects of defined size were created in the frontal skull of domestic pigs and filled with DBBM alone (group A) and DBBM+25%AB (group B). De novo bone formation was analyzed qualitatively and quantitatively at 9 different times (0.5, 1, 2, 3, 4, 6, 8, 12, 26 weeks) by means of light microscopy, microradiography, and statistical analysis.
RESULTS
Histological analysis indicated sufficient osseointegration of DBBM in both groups. Microradiography demonstrated a significant increase of bone formation in group B after 6 weeks (P = .0159) and 8 weeks (P = .0317).
CONCLUSION
The addition of 25%AB to DBBM results in accelerated de novo bone formation in osseous defects. This effect is likely caused by osteoinductive properties of cellular elements transplanted with the autogenous bone.
目的
本前瞻性动物研究检测了在骨缺损处应用脱蛋白牛骨基质（DBBM）单独或联合自体骨（AB）时的新生骨形成情况。
研究设计
在家猪的额骨上制造特定大小的缺损，并分别用单纯DBBM（A组）和DBBM + 25% AB（B组）填充。在9个不同时间点（0.5、1、2、3、4、6、8、12、26周）通过光学显微镜、显微放射ography和统计分析对新生骨形成进行定性和定量分析。
结果
组织学分析表明两组中DBBM均有充分的骨整合。显微放射ography显示B组在6周（P = .0159）和8周（P = .0317）后骨形成显著增加。
结论
向DBBM中添加25% AB可加速骨缺损处的新生骨形成。这种效应可能是由与自体骨一起移植的细胞成分的骨诱导特性引起的。
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