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胆囊上皮中maspin表达异常与胆石症患者的肠化生有关。

Aberrant maspin expression in gallbladder epithelium is associated with intestinal metaplasia in patients with cholelithiasis.

作者信息

Maesawa C, Ogasawara S, Yashima-Abo A, Kimura T, Kotani K, Masuda S, Nagata Y, Iwaya T, Suzuki K, Oyake T, Akiyama Y, Kawamura H, Masuda T

机构信息

Department of Pathology, Iwate Medical University School of Medicine, Uchimaru 19-1, 020-8505 Morioka, Japan.

出版信息

J Clin Pathol. 2006 Mar;59(3):328-30. doi: 10.1136/jcp.2005.027284.

DOI:10.1136/jcp.2005.027284
PMID:16505288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1860347/
Abstract

OBJECTIVE

Aberrant expression of maspin protein related to DNA hypomethylation in the promoter region is frequently observed in gallbladder carcinomas, whereas the non-tumorous gallbladder epithelium is maspin negative. We investigated maspin expression in non-tumorous gallbladder epithelium in patients with cholelithiasis.

METHODS

An immunohistochemical study of maspin expression was performed in 69 patients with cholelithiasis and 30 patients with gastric cancer without cholelithiasis.

RESULTS

Immunoreactivity for maspin was observed in focal and patchy regions of the gallbladder epithelium. Positive immunoreactivity for maspin was significantly associated with the presence of intestinal metaplasia in patients with cholelithiasis (p<0.05).

CONCLUSION

The high incidence of aberrant maspin expression in both intestinal metaplasia and carcinoma of the gallbladder supports the assumption that intestinal metaplasia of the gallbladder may predispose to gallbladder carcinoma.

摘要

目的

在胆囊癌中经常观察到与启动子区域DNA低甲基化相关的maspin蛋白异常表达，而非肿瘤性胆囊上皮maspin呈阴性。我们研究了胆石症患者非肿瘤性胆囊上皮中maspin的表达。

方法

对69例胆石症患者和30例无胆石症的胃癌患者进行了maspin表达的免疫组织化学研究。

结果

在胆囊上皮的局灶性和散在区域观察到maspin免疫反应性。胆石症患者中maspin阳性免疫反应性与肠化生的存在显著相关（p<0.05）。

结论

胆囊肠化生和胆囊癌中maspin异常表达的高发生率支持了胆囊肠化生可能易患胆囊癌的假设。

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J Clin Pathol. 2006 Mar;59(3):328-30. doi: 10.1136/jcp.2005.027284.
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J Cancer Res Clin Oncol. 2005 May;131(5):271-8. doi: 10.1007/s00432-004-0658-4. Epub 2005 Jan 11.
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Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients.胃癌患者中CDX2基因甲基化与饮食因素的关系
Carcinogenesis. 2005 Jan;26(1):193-200. doi: 10.1093/carcin/bgh304. Epub 2004 Oct 21.
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Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis.CDX2的异常表达与肝内胆管结石病患者肝内导管内乳头状肿瘤的肠化生及MUC2表达密切相关。
Lab Invest. 2004 May;84(5):629-38. doi: 10.1038/labinvest.3700087.
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Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers.Maspin基因启动子处细胞类型特异性甲基化的破坏经常与未分化甲状腺癌有关。
Oncogene. 2004 Feb 5;23(5):1117-24. doi: 10.1038/sj.onc.1207211.
6
Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control.人类胰腺癌细胞通过表观遗传控制的丧失来激活丝氨酸蛋白酶抑制剂（maspin）的表达。
Neoplasia. 2003 Sep-Oct;5(5):427-36. doi: 10.1016/s1476-5586(03)80045-3.
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