Lakshmi V, Ashok R, Susmita J, Shailaja V V
Department of Microbiology, Nizam's Institute of Medical Sciences, Hyderabad-500 082, Andhra Pradesh, India.
Indian J Med Microbiol. 2006 Jan;24(1):45-8. doi: 10.4103/0255-0857.19894.
The present study was undertaken to compare the changing trends of antibiograms of Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi A isolates. A total of 80 isolates of salmonella obtained from blood cultures between 2001-2004 were included in the study. Identification and antibiotic sensitivities of the isolates were performed by using mini API (bio Merieux, France). Sixty isolates were identified as Salmonella enterica serovar Typhi and 20 were identified as Salmonella enterica serovar Paratyphi A. More than 67% of S.typhi and 80% of S.paratyphi A isolates were sensitive to chloramphenicol. Sensitivity of S.typhi isolates to cephalosporins was found to have increased from 2001-2004 while that of S.paratyphi A showed a decline. With increasing resistance to ciprofloxacin and the possibility of re-emergence of sensitivity to chloramphenicol, the policy of empirical treatment of enteric fever needs to be rationalized.
本研究旨在比较伤寒沙门氏菌和甲型副伤寒沙门氏菌分离株的抗菌谱变化趋势。该研究纳入了2001年至2004年间从血培养中获得的80株沙门氏菌分离株。使用微型API（法国生物梅里埃公司）对分离株进行鉴定和抗生素敏感性检测。60株被鉴定为伤寒沙门氏菌，20株被鉴定为甲型副伤寒沙门氏菌。超过67%的伤寒沙门氏菌和80%的甲型副伤寒沙门氏菌分离株对氯霉素敏感。发现2001年至2004年间伤寒沙门氏菌分离株对头孢菌素的敏感性有所增加，而甲型副伤寒沙门氏菌的敏感性则呈下降趋势。随着对环丙沙星耐药性的增加以及对氯霉素敏感性可能重新出现，肠热症的经验性治疗策略需要合理化。
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