Lysle D T, Cunnick J E, Maslonek K A
Department of Psychology, University of North Carolina, Chapel Hill 27599-3270.
Behav Neurosci. 1991 Jun;105(3):443-9. doi: 10.1037//0735-7044.105.3.443.
The effect of propranolol, a beta-adrenergic receptor antagonist, on the suppression of splenic mitogenic responsiveness induced by an aversive conditioned stimulus (CS) was evaluated in rats. Experiment 1 demonstrated that propranolol administration before presentation of the CS completely blocked the suppressive effect. In contrast, Experiment 2 showed that administration of propranolol during the training of the aversive CS had no effect on the suppressive effect of the CS in a subsequent test. These findings indicate that the release of catecholamines is responsible for the conditioned immune alteration of splenic lymphocytes. Taken further, these findings suggest that the learning of the conditioned immunomodulatory response to an aversive CS is a Pavlovian conditioning process that is not dependent on the performance of the conditioned response during training.
在大鼠中评估了β-肾上腺素能受体拮抗剂普萘洛尔对厌恶条件刺激（CS）诱导的脾有丝分裂反应性抑制的影响。实验1表明，在呈现CS之前给予普萘洛尔可完全阻断抑制作用。相比之下，实验2表明，在厌恶CS训练期间给予普萘洛尔对后续测试中CS的抑制作用没有影响。这些发现表明，儿茶酚胺的释放是脾淋巴细胞条件性免疫改变的原因。进一步而言，这些发现表明，对厌恶CS的条件性免疫调节反应的学习是一种巴甫洛夫条件反射过程，不依赖于训练期间条件反应的表现。
