Lysle D T, Luecken L J, Maslonek K A
Department of Psychology, University of North Carolina, Chapel Hill 27599-3270.
Brain Behav Immun. 1992 Mar;6(1):64-73. doi: 10.1016/0889-1591(92)90060-2.
The present study evaluated the effect of a conditioned aversive stimulus (CS) on the development of adjuvant-induced arthritis in Lewis rats. Experiment 1 showed that presentation of a CS, on days 12, 14, and 16 following injection with adjuvant containing mycobacterium tuberculosis, resulted in a pronounced suppression of the development of arthritis as measured by a clinical disease severity rating scale and spleen weight. In contrast, presentation of the CS on days 0, 2, and 4 following injection did not have any effect on the development of arthritis. Experiment 2 showed that the suppression of adjuvant arthritis by exposure to the CS was blocked by administration of propranolol, a nonselective beta-adrenergic receptor antagonist. These results demonstrate that a CS can alter the development of adjuvant-induced arthritis, but the effect is dependent upon the timing of the antigen exposure and the presentation of the CS. Moreover, the present findings suggest that blocking beta-adrenergic receptors during presentations of the CS prevents the suppressive effect of the CS.
本研究评估了条件性厌恶刺激（CS）对Lewis大鼠佐剂性关节炎发展的影响。实验1表明，在注射含结核分枝杆菌的佐剂后的第12、14和16天给予CS，通过临床疾病严重程度评分量表和脾脏重量测量，可显著抑制关节炎的发展。相比之下，在注射后的第0、2和4天给予CS对关节炎的发展没有任何影响。实验2表明，给予普萘洛尔（一种非选择性β-肾上腺素能受体拮抗剂）可阻断暴露于CS对佐剂性关节炎的抑制作用。这些结果表明，CS可改变佐剂性关节炎的发展，但其效果取决于抗原暴露的时间和CS的给予时间。此外，目前的研究结果表明，在给予CS期间阻断β-肾上腺素能受体可防止CS的抑制作用。
