Fraser N W, Spivack J G, Wroblewska Z, Block T, Deshmane S L, Valyi-Nagy T, Natarajan R, Gesser R M
Wistar Institute, Philadelphia, PA 19104.
Curr Eye Res. 1991;10 Suppl:1-13. doi: 10.3109/02713689109020352.
The neurotropic herpes viruses, as typified by herpes simplex virus type 1, are noted for their ability to form latent infections. The latent infection differs from the acute infection both in gene expression and the physical state of the viral genome. Latency can be divided into several stages--establishment, maintenance of reactivation--each of which are active areas of research. This review describes the molecular biology of HSV-1 latency and presents the current level of understanding of the molecular mechanism of HSV-1 latency.
以1型单纯疱疹病毒为代表的嗜神经疱疹病毒，以其形成潜伏感染的能力而闻名。潜伏感染在基因表达和病毒基因组的物理状态方面均与急性感染有所不同。潜伏期可分为几个阶段——建立、维持和再激活——每个阶段都是活跃的研究领域。本综述描述了HSV-1潜伏的分子生物学，并介绍了目前对HSV-1潜伏分子机制的理解水平。
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