Willey D E, Williams I, Faucett C, Openshaw H
Department of Neurology, City of Hope National Medical Center, Duarte, CA 91010.
Curr Eye Res. 1991;10 Suppl:167-9. doi: 10.3109/02713689109020374.
Discs 1.6 mm in diameter trephined from corneal collagen shields were used to deliver acyclovir (ACV) to the cornea of mice inoculated with herpes simplex virus type 1 (HSV-1). In the first minute after application to the cornea, there was a 23% decrease of ACV in the discs. After the first minute, ACV clearance from the discs appeared to be exponential with a half-life of 21 minutes. Treatment given 3 times a day reduced HSV-1 titer in tear film, corneal tissue, and trigeminal ganglia. This animal model should be useful to conserve novel potential anti-viral drugs undergoing initial screening.
从角膜胶原盾上切下直径1.6毫米的圆盘用于将阿昔洛韦（ACV）递送至接种单纯疱疹病毒1型（HSV-1）的小鼠角膜。应用于角膜后的第一分钟内，圆盘中的阿昔洛韦减少了23%。第一分钟后，阿昔洛韦从圆盘中的清除似乎呈指数关系，半衰期为21分钟。一天给药3次可降低泪膜、角膜组织和三叉神经节中的HSV-1滴度。这种动物模型对于保存正在进行初步筛选的新型潜在抗病毒药物应该是有用的。
