Shiota H, Naito T, Mimura Y
Curr Eye Res. 1987 Jan;6(1):241-5. doi: 10.3109/02713688709020098.
The anti-herpes simplex virus (HSV) effect and cytotoxicity of a new nucleoside analogue, 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in rabbit cornea were studied. In tests of the anti-HSV effect of DHPG, even 0.03% ointment, given 5 times per day for 2 days, prevented lesion formation. The preventive effect of DHPG was much stronger than that of acyclovir (ACV) or 5-iodo-2'-deoxyuridine (IDU). In tests on the therapeutic effect of DHPG against dendritic ulcers, 0.3% ointment, given 5 times per day for 4 days, had a dramatic therapeutic effect. The effect was stronger than that of 3% ACV or 0.5% IDU ointment. Application of 0.3%, 1% or 3% DHPG ointment to normal rabbit corneas, 5 times per day for 2 weeks resulted in no histopathological abnormalities. The above results show that DHPG is superior to ACV or IDU for treatment of HSV infections.
研究了一种新的核苷类似物9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤（DHPG）在兔角膜中的抗单纯疱疹病毒（HSV）作用和细胞毒性。在DHPG的抗HSV作用试验中，即使是0.03%的软膏，每天给药5次，持续2天，也能预防病变形成。DHPG的预防作用比阿昔洛韦（ACV）或5-碘-2'-脱氧尿苷（IDU）强得多。在DHPG对树枝状溃疡的治疗效果试验中，0.3%的软膏，每天给药5次，持续4天，具有显著的治疗效果。该效果比3%的ACV或0.5%的IDU软膏更强。将0.3%、1%或3%的DHPG软膏应用于正常兔角膜，每天5次，持续2周，未导致组织病理学异常。上述结果表明，在治疗HSV感染方面，DHPG优于ACV或IDU。
