Colin J, Malet F, Chastel C, Richard M C
Brest University Hospital, France.
Curr Eye Res. 1991;10 Suppl:189-91. doi: 10.3109/02713689109020378.
Eighteen patients with typical Herpes simplex virus dendritic keratitis confirmed by viral isolation were treated with corneal collagen shields presoaked with trifluorothymidine for 15 minutes and trifluorothymidine eye drops 5 times daily. The average healing time was 2.9 days (range 1-7 days). No allergic reactions were observed. Toxic punctate keratitis occurred in 3 eyes. The results of this open study suggest that the effect of collagen corneal shields in conjunction with trifluorothymidine shortens the average epithelial healing time compared with other studies that have used antiviral drugs alone.
18例经病毒分离确诊为典型单纯疱疹病毒性树枝状角膜炎的患者，使用预先用三氟胸腺嘧啶浸泡15分钟的角膜胶原盾并每日5次滴用三氟胸腺嘧啶眼药水进行治疗。平均愈合时间为2.9天（范围1 - 7天）。未观察到过敏反应。3只眼发生了毒性点状角膜炎。这项开放性研究的结果表明，与其他仅使用抗病毒药物的研究相比，胶原角膜盾联合三氟胸腺嘧啶可缩短平均上皮愈合时间。
