Zhou X D
Liver Cancer Institute, Shanghai Medical University.
Zhonghua Wai Ke Za Zhi. 1991 Feb;29(2):87-9, 141.
We reported the results of hepatic artery ligation (HAL) and infusion (HAI) with chemotherapy in the treatment of 356 patients with nonresectable primary liver cancer (PLC). A comparison of data between the periods 1958-1977 (81 cases) and 1978-1989 (275 cases) revealed that remarkable improvement in survival in the latter period might be attributed to the accurate site of hepatic artery cannulation, long-term infusion with chemotherapy, and combined treatment with subsequent tumor resection. During 1978-1989, the 5-year survival rates of different treatment modalities were 0% in HAL (n = 36) alone, 7.9% in HAI (n = 67) alone, 24.4% in HAL + HAI (n = 112, with subsequent resection in 10 cases), 36.5% in HAL + HAI + radiation (internal and/or external) (n = 60, with subsequent resection in 19 cases). The results indicate that HAL + HAI + combined treatment might provide a hope for the prolongation of survival or even resection in some patients with nonresectable PLC.
我们报告了肝动脉结扎术（HAL）和肝动脉灌注化疗（HAI）治疗356例不可切除的原发性肝癌（PLC）患者的结果。对1958 - 1977年（81例）和1978 - 1989年（275例）两个时期的数据比较显示，后一时期生存率的显著提高可能归因于肝动脉插管部位准确、长期化疗灌注以及随后联合肿瘤切除术。1978 - 1989年期间，不同治疗方式的5年生存率分别为：单纯HAL（n = 36）为0%，单纯HAI（n = 67）为7.9%，HAL + HAI（n = 112，其中10例随后行切除术）为24.4%，HAL + HAI +放疗（内照射和/或外照射）（n = 60，其中19例随后行切除术）为36.5%。结果表明，HAL + HAI +联合治疗可能为一些不可切除的PLC患者延长生存期甚至实现切除带来希望。
