Giacchino R, Navone C, Facco F, Giambartolomei G, Pontisso P, Callea F
I Department of Infectious Diseases, University of Genova, Italy.
Dig Dis Sci. 1991 Aug;36(8):1143-6. doi: 10.1007/BF01297462.
In a series of 325 HBV chronically infected children observed over an 18-year period, three developed HCC. These three children were born in southern Italy, a region characterized by a high endemic HBV infection rate; each had been infected perinatally, developed an acute hepatitis, and became a chronic carrier. Two of the three with cirrhosis were HBsAg positive at the time their HCC was detected. The remaining case had seroconverted to HBsAb but HBV-DNA integration could be demonstrated in the absence of cirrhosis; moreover HBV antigens were not expressed in the tissue of this case. The interval between HBV infection and HCC appearance in these three cases ranged from six to 11 years. A similarity between these three Italian cases and the majority of HCC arising in chronically infected children in the Far East is noted.
在一项对325名慢性感染乙肝病毒的儿童进行了18年观察的研究中，有3名儿童患上了肝癌。这3名儿童出生于意大利南部，该地区乙肝病毒感染率很高；他们均在围产期感染，曾患急性肝炎，之后成为慢性携带者。在这3名患肝硬化的儿童中，有2名在肝癌被检测出时乙肝表面抗原呈阳性。其余1例已血清转化为乙肝表面抗体，但在无肝硬化的情况下可证实存在乙肝病毒DNA整合；此外，该病例组织中未表达乙肝病毒抗原。这3例中乙肝病毒感染与肝癌出现的间隔时间为6至11年。注意到这3例意大利病例与远东地区大多数慢性感染儿童所患肝癌之间存在相似性。
