Shimizu T, Shishiba Y
Endocrinol Jpn. 1975 Feb;22(1):55-60. doi: 10.1507/endocrj1954.22.55.
T3 or iodide, at the concentration of 10- minus 3M, inhibits TSH- or dibutyryl-cyclic AMP-induced thyroidal intracellular colloid droplet formation, while leaving the TSH-induced increase in cyclic AMP levels intact. The effect of T3 appeared not to be mediated through the iodide derived from deiodination of T3. Those results clearly demonstrate that T3 or iodide acts at the point beyond cyclic AMP generation and prior tothe formation of intracellular colloid droplets. This is also the site at which microtubule active reagents exert their influence. Whether T3 or iodide fits this category or acts in as yet undetermined manner remains to be established.
浓度为10⁻³M的三碘甲状腺原氨酸（T3）或碘化物可抑制促甲状腺激素（TSH）或二丁酰环磷酸腺苷（dibutyryl-cyclic AMP）诱导的甲状腺细胞内胶体小滴形成，而TSH诱导的环磷酸腺苷水平升高则不受影响。T3的作用似乎不是通过T3脱碘产生的碘化物介导的。这些结果清楚地表明，T3或碘化物作用于环磷酸腺苷生成之后、细胞内胶体小滴形成之前的环节。这也是微管活性试剂发挥作用的位点。T3或碘化物是否属于这一类别或以尚未确定的方式起作用仍有待确定。
