Judd R, Zaki S R, Coffield L M, Evatt B L
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322.
Hum Pathol. 1991 Jun;22(6):550-6. doi: 10.1016/0046-8177(91)90231-d.
A series of 19 paraffin-embedded sinonasal papillomas (four squamous papillomas, three fungiform papillomas, nine inverted papillomas, and three cylindrical cell papillomas) were investigated for evidence of human papillomavirus (HPV) infection using immunohistochemistry (polyclonal antibody to HPV capsid antigen), in situ hybridization (DNA probes for HPV 6/11, 16/18, and 31/33/35), and the polymerase chain reaction (primers and probes for HPV 6, 11, 16, 18, and 33). All three fungiform papillomas were positive by all three techniques: immunohistochemistry, in situ hybridization for HPV 6/11, and the polymerase chain reaction for HPV 11. None of the other lesions contained detectable HPV using the specific probes included in this study. These results support the continued classification of fungiform papilloma as a distinctive variant of schneiderian papilloma characterized by a predominantly exophytic growth pattern and an association with HPV 11.
对19例石蜡包埋的鼻窦乳头状瘤（4例鳞状乳头状瘤、3例蕈状乳头状瘤、9例内翻性乳头状瘤和3例柱状细胞乳头状瘤）进行研究，采用免疫组织化学（抗人乳头瘤病毒（HPV）衣壳抗原多克隆抗体）、原位杂交（HPV 6/11、16/18和31/33/35的DNA探针）以及聚合酶链反应（HPV 6、11、16、18和33的引物及探针）检测HPV感染证据。所有3例蕈状乳头状瘤在免疫组织化学、HPV 6/11原位杂交及HPV 11聚合酶链反应这三种技术检测中均呈阳性。使用本研究中包含的特异性探针，其他病变均未检测到HPV。这些结果支持将蕈状乳头状瘤持续分类为施耐德乳头状瘤的一种独特变体，其特征为主要呈外生性生长模式并与HPV 11相关。
