Brandwein M, Steinberg B, Thung S, Biller H, Dilorenzo T, Galli R
Lillian and Henry M. Stratton-Hans Popper Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029.
Cancer. 1989 May 1;63(9):1708-13. doi: 10.1002/1097-0142(19900501)63:9<1708::aid-cncr2820630911>3.0.co;2-9.
Schneiderian inverted papillomas may be troublesome lesions for clinicians with propensity for recurrences. Dysplasia is not uncommonly seen, and some of these lesions do progress to develop squamous carcinoma. The authors hybridized in situ seven inverted papillomas with RNA probes to human papillomavirus (HPV) 6, 11, 16, and 18. Four of these contained dysplasia, two were without dysplasia, and one contained invasive squamous cell carcinoma. Five inverted papillomas showed evidence of HPV infection based on hybridization. One with mild to moderate and one with severe dysplasia, and one without dysplasia hybridized with mixed probe HPV 6/11. One with mild dysplasia and one associated with invasive squamous cell carcinoma hybridized with mixed probe HPV 16/18. One inverted papilloma without dysplasia and one with severe dysplasia did not definitively hybridize with either mixed probe. These findings raise interesting questions as to role of HPV 6/11 and 16/18 in the development of inverted papillomas, and probably on the progression to and carcinoma.
鼻窦内翻性乳头状瘤对于临床医生而言可能是棘手的病变，具有复发倾向。发育异常并不少见，其中一些病变确实会进展为鳞状细胞癌。作者用针对人乳头瘤病毒（HPV）6、11、16和18的RNA探针，对7例鼻窦内翻性乳头状瘤进行了原位杂交。其中4例有发育异常，2例无发育异常，1例有浸润性鳞状细胞癌。基于杂交结果，5例鼻窦内翻性乳头状瘤显示有HPV感染证据。1例轻度至中度发育异常和1例重度发育异常以及1例无发育异常的病例与混合探针HPV 6/11杂交。1例轻度发育异常和1例伴有浸润性鳞状细胞癌的病例与混合探针HPV 16/18杂交。1例无发育异常的鼻窦内翻性乳头状瘤和1例重度发育异常的病例均未与任一混合探针进行明确杂交。这些发现就HPV 6/11和16/18在鼻窦内翻性乳头状瘤发生发展以及可能进展为癌的过程中的作用，提出了有趣的问题。
