Franke Andreas, Teyssen Stephan, Singer Manfred V
Department of Medicine II (Gastroenterology, Hepatology, Infectious Diseases), University Hospital Mannheim, University of Heidelberg, Mannheim, Germany.
Dig Dis. 2005;23(3-4):204-13. doi: 10.1159/000090167.
The present review summarizes the clinically relevant effects of acute and chronic alcohol consumption on motility, mucosal inflammation and cancer of the esophagus and the stomach. Alcohol consumption results in a significant increase in the morbidity of these two organs, the most important probably being the significant increase in the development of esophageal cancer. This review refers to epidemiologic and systematic experimental data to elucidate the clinical impact of alcohol consumption as well as the underlying alcohol-induced pathophysiologic mechanisms for these esophageal and gastric diseases. Much research is still needed to clarify the effects of alcohol itself and the byproducts that result during the production of the different types of alcoholic beverages on dismotility and mucosal injury to the esophagus and stomach.
本综述总结了急性和慢性饮酒对食管和胃的动力、黏膜炎症及癌症的临床相关影响。饮酒导致这两个器官的发病率显著增加，其中最重要的可能是食管癌发病率的显著上升。本综述参考了流行病学和系统性实验数据，以阐明饮酒的临床影响以及酒精诱导的这些食管和胃部疾病的潜在病理生理机制。仍需大量研究来阐明酒精本身以及不同类型酒精饮料生产过程中产生的副产品对食管和胃动力障碍及黏膜损伤的影响。
