Angst Martin S, Clark J David
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305-5117, USA.
Anesthesiology. 2006 Mar;104(3):570-87. doi: 10.1097/00000542-200603000-00025.
Opioids are the cornerstone therapy for the treatment of moderate to severe pain. Although common concerns regarding the use of opioids include the potential for detrimental side effects, physical dependence, and addiction, accumulating evidence suggests that opioids may yet cause another problem, often referred to as opioid-induced hyperalgesia. Somewhat paradoxically, opioid therapy aiming at alleviating pain may render patients more sensitive to pain and potentially may aggravate their preexisting pain. This review provides a comprehensive summary of basic and clinical research concerning opioid-induced hyperalgesia, suggests a framework for organizing pertinent information, delineates the status quo of our knowledge, identifies potential clinical implications, and discusses future research directions.
阿片类药物是治疗中度至重度疼痛的基石疗法。尽管对阿片类药物使用的常见担忧包括可能产生有害副作用、身体依赖和成瘾，但越来越多的证据表明，阿片类药物可能还会引发另一个问题，通常称为阿片类药物诱导的痛觉过敏。有点自相矛盾的是，旨在减轻疼痛的阿片类药物治疗可能会使患者对疼痛更加敏感，并有可能加重他们原有的疼痛。本综述全面总结了关于阿片类药物诱导的痛觉过敏的基础和临床研究，提出了一个组织相关信息的框架，阐述了我们的知识现状，确定了潜在的临床意义，并讨论了未来的研究方向。
