Chen Ching K, Low Yee, Akhilesh Meenakshi, Jacobsen Anette S
Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore.
J Paediatr Child Health. 2006 Mar;42(3):104-7. doi: 10.1111/j.1440-1754.2006.00806.x.
Kikuchi disease is a benign, self-limiting condition of unknown aetiology, often manifesting as cervical lymphadenopathy and fever. The disease usually manifests itself in adulthood and paediatric reports are uncommon. The aims of this study are to report the features of Kikuchi disease in the local paediatric population, and to raise the awareness of this entity among clinicians involved in treating these children.
This is a retrospective series of nine paediatric cases of Kikuchi disease treated in KK Women's and Children's Hospital, Singapore. The clinical presentation, subsequent clinical course and laboratory findings of these patients were reviewed.
The patients ranged in age from 7 to 16 years, and included six males and three females. All nine patients presented with fever and cervical lymphadenopathy. Hepatosplenomegaly was present in one child. The erythrocyte sedimentation rate was raised to variable extents, but there was no other significant haematological, serological or microbiological abnormality. In all cases the diagnosis was made on the basis of histological findings.
Kikuchi disease in the paediatric population is not as uncommon as previously thought, and should be considered in the differential diagnosis of any child with fever of unknown origin or cervical lymphadenopathy. Early recognition will minimize unnecessary investigations and prolonged empirical treatments.
菊池病是一种病因不明的良性自限性疾病，常表现为颈部淋巴结病和发热。该病通常在成年期发病，儿科病例报告并不常见。本研究的目的是报告本地儿科人群中菊池病的特征，并提高参与治疗这些儿童的临床医生对该疾病的认识。
这是一项对新加坡KK妇女儿童医院收治的9例儿科菊池病病例的回顾性研究。回顾了这些患者的临床表现、后续病程及实验室检查结果。
患者年龄在7至16岁之间，其中6例为男性，3例为女性。所有9例患者均有发热和颈部淋巴结病。1例患儿有肝脾肿大。红细胞沉降率有不同程度升高，但无其他明显的血液学、血清学或微生物学异常。所有病例均根据组织学检查结果确诊。
儿科人群中的菊池病并不像以前认为的那么罕见，对于任何不明原因发热或颈部淋巴结病的儿童，在鉴别诊断时都应考虑该病。早期识别将减少不必要的检查和长期的经验性治疗。
