Al-Nazer Mona A, Al-Hadad Ali M, Al-Aithan Soror A, Al-Salem Ahmed H, Al-Faraj Ahmed A, Al-Saeed Hussain H
Department of Histopathology, Qatif Central Hospital, PO Box 18478, Al Jesh 31911, Qatif, Kingdom of Saudi Arabia.
Saudi Med J. 2002 Apr;23(4):405-8.
Kukuchi-Fujimito disease is a rare, benign and self limiting condition, which usually presents with lymphadenopathy or fever of an unknown etiology, or both. Its rarity, as well as the similarity of its clinical features to other more common conditions, contribute to overlooking it in the differential diagnosis of patients presenting with lymphadenopathy or fever of an unknown etiology.
The study was carried out at Qatif Central Hospital, Qatif, Kingdom of Saudi Arabia. All lymph node excisional biopsies received in the histopathology laboratory between 1989 and 1999 were evaluated and those diagnosed as Kukuchi-Fujimito disease were reviewed for clinical data and histological findings.
A total of 6 cases were diagnosed as Kukuchi-Fujimito disease out of 390 lymph node biopsies. All patients were young with an average age of 21.5 years and equal sex distribution. Enlarged cervical lymph nodes with or without fever were the most familiar presenting symptoms. Anemia and leukopenia were observed in 3 patients. There was no recurrence of the lymphadenopathy over a period of 1-12 years follow up.
Kukuchi-Fujimito disease although rare should be included in the differential diagnosis of patients presenting with lymphadenopathy as well as fever of an unknown origin. To obviate unnecessary investigations and therapeutic trials, these patients should undergo early lymph node biopsy which must be interpreted by an experienced pathologist.
久口古-藤本病是一种罕见的良性自限性疾病，通常表现为淋巴结病或不明原因发热，或两者兼有。其罕见性以及临床特征与其他更常见疾病的相似性，导致在对出现淋巴结病或不明原因发热的患者进行鉴别诊断时容易忽略该病。
本研究在沙特阿拉伯王国卡提夫的卡提夫中心医院开展。对1989年至1999年间组织病理学实验室接收的所有淋巴结切除活检标本进行评估，并对诊断为久口古-藤本病的病例的临床资料和组织学发现进行回顾。
在390例淋巴结活检中，共有6例被诊断为久口古-藤本病。所有患者均为年轻人，平均年龄21.5岁，男女比例均等。伴有或不伴有发热的颈部淋巴结肿大是最常见的症状。3例患者出现贫血和白细胞减少。在1至12年的随访期内，淋巴结病未复发。
久口古-藤本病虽罕见，但在对出现淋巴结病以及不明原因发热的患者进行鉴别诊断时应予以考虑。为避免不必要的检查和治疗试验，这些患者应尽早进行淋巴结活检，且活检结果必须由经验丰富的病理学家解读。
