Nebesio Todd D, Eugster Erica A
Department of Pediatrics, James Whitcomb Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Pediatrics. 2006 Mar;117(3):951-4. doi: 10.1542/peds.2005-1227.
Pubic hair of infancy is a rare condition that has not been well-characterized. A retrospective chart review of infants <12 months of age who presented to our pediatric endocrine clinics with isolated pubic hair over the last 5 years was performed. Eleven patients were identified (6 male and 5 female). The average age at diagnosis was 8.3 +/- 2.0 months. The majority of patients (73%) had pubic hair in an atypical location. Growth pattern, laboratory evaluation, and bone-age radiographs were unremarkable for all the infants. Of the infants that returned for follow-up, pubic hair resolved by the age of 11.0 +/- 1.5 months. From our experience and review of the literature, we suggest that isolated pubic hair of infancy is a benign entity. However, long-term follow-up needs to be done to determine if pubic hair of infancy is an atypical variant of premature adrenarche, which may place these patients at risk for later adult disease.
婴儿期出现阴毛是一种罕见的情况，目前尚未得到充分的特征描述。我们对过去5年到我们儿科内分泌门诊就诊的12个月以下、仅有阴毛的婴儿进行了回顾性病历审查。共确定了11名患者（6名男性和5名女性）。诊断时的平均年龄为8.3±2.0个月。大多数患者（73%）的阴毛分布在非典型部位。所有婴儿的生长模式、实验室检查和骨龄X光片均无异常。在接受随访的婴儿中，阴毛在11.0±1.5个月龄时消失。根据我们的经验和文献回顾，我们认为婴儿期孤立性阴毛是一种良性现象。然而，需要进行长期随访以确定婴儿期阴毛是否是早熟肾上腺功能初现的非典型变体，这可能使这些患者面临日后患成人疾病的风险。
