Muhsen Kh, Athamna A, Athamna M, Spungin-Bialik A, Cohen D
Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Epidemiol Infect. 2006 Oct;134(5):990-6. doi: 10.1017/S0950268806006030. Epub 2006 Mar 2.
We determined the prevalence and risk factors of H. pylori infection among 197 healthy 3- to 5-year-old Israeli Arab children, in a population under socioeconomic and environmental transition. Data on the socioeconomic and environmental characteristics were obtained by personal interviews. The presence of H. pylori infection was identified using an ELISA kit for detection of H. pylori antigens in stool specimens. The prevalence rate of H. pylori infection was 49.7% (95% CI 42.8-56.67). It varied significantly among the different villages. In the univariate analysis stratified by village, the risk of infection increased according to household crowding, number of siblings younger than 5 years and siblings' H. pylori positivity. In the multivariate analysis the village of residence and siblings' H. pylori positivity were the only variables that remained strongly associated with H. pylori infection. In a population such as that described in this study the socioeconomic and living conditions are major risk factors of H. pylori infection and the intra-familial transmission of H. pylori in early childhood has an important role.
我们在一个处于社会经济和环境转型期的人群中，对197名3至5岁健康的以色列阿拉伯儿童进行了幽门螺杆菌感染率及危险因素的研究。通过个人访谈获取社会经济和环境特征数据。采用酶联免疫吸附测定（ELISA）试剂盒检测粪便标本中幽门螺杆菌抗原，以确定是否存在幽门螺杆菌感染。幽门螺杆菌感染率为49.7%（95%可信区间42.8 - 56.67）。不同村庄之间感染率差异显著。在按村庄分层的单因素分析中，感染风险随着家庭拥挤程度、5岁以下兄弟姐妹数量以及兄弟姐妹幽门螺杆菌阳性情况而增加。多因素分析显示，居住村庄和兄弟姐妹幽门螺杆菌阳性是与幽门螺杆菌感染仍密切相关的仅有的变量。在本研究描述的这类人群中，社会经济和生活条件是幽门螺杆菌感染的主要危险因素，儿童早期幽门螺杆菌的家庭内传播起着重要作用。
