Hayes H M, Priester W A, Pendergrass T W
Int J Cancer. 1975 Jan 15;15(1):39-47. doi: 10.1002/ijc.2910150106.
From 11 North American veterinary university hospitals and clinics, 248 animals were a confirmed diagnosis of nervous-tissue tumor were identified; 7 tumors were found in cattle, 28 in horses, 14 in cats, 199 in dogs, and none in other species. Tumors were divided for analysis into three categories-glial, meningeal, and peripheral nerve. In cattle and horses, all tumors involved peripheral nerves, the risk of which, in horses, reached a plateau at 4-6 years of age and remained constant thereafter. In cats, the tumors were equally distributed among the three tumor categories whereas, in dogs, twice as many glial tumors as meningeal and peripheral nerve tumors were found. The risk for glial tumors in dogs reached a peak at 10-14 years of age, for meningeal at 7-9 years, and for peripheral nerve at 2-3 and 7-9 years. Three canine breeds-English bulldog, boxer, and Boston terrier-had an excessive rish of glial tumors. Except for an excess of skin tumors in dogs with peripheral nerve tumors, there was no unusual occurrence with second primary neoplasms for any species. There was no detectable predisposition by sex for any of the categories of nervous-tissue tumors among any of the four species. The role of genetic abnormalities associated with nervous-tissue tumors and other etiologic factors (e.g., chronic hypoxia) may be clarified by further studies involving canine breeds of "bulldog" ancestry.
在11家北美兽医大学医院和诊所中，确诊患有神经组织肿瘤的动物有248只；其中牛有7只肿瘤，马有28只，猫有14只，狗有199只，其他物种未发现肿瘤。肿瘤被分为三类进行分析——神经胶质、脑膜和周围神经。在牛和马中，所有肿瘤都累及周围神经，在马中，其风险在4至6岁时达到平稳状态，此后保持稳定。在猫中，肿瘤在这三类肿瘤中分布均匀，而在狗中，发现的神经胶质肿瘤数量是脑膜和周围神经肿瘤的两倍。狗中神经胶质肿瘤的风险在10至14岁时达到峰值，脑膜肿瘤在7至9岁时达到峰值，周围神经肿瘤在2至3岁和7至9岁时达到峰值。三种犬种——英国斗牛犬、拳师犬和波士顿梗——患神经胶质肿瘤的风险过高。除了患有周围神经肿瘤的狗皮肤肿瘤过多外，任何物种的第二原发性肿瘤都没有异常发生。在这四个物种中，任何一类神经组织肿瘤在性别上都没有可检测到的易感性。与神经组织肿瘤相关的基因异常和其他病因（如慢性缺氧）的作用，可能通过对有“斗牛犬”血统的犬种进行进一步研究来阐明。
