Suleiman M, Duc C, Ritz S, Bieri S
Department of Radiooncology, Hospital of Sion, Sion, Switzerland.
Int J Gynecol Cancer. 2006 Jan-Feb;16 Suppl 1:356-60. doi: 10.1111/j.1525-1438.2006.00218.x.
Aggressive angiomyxoma (AAM) is a rare tumor that preferentially involves the pelvis and perineal regions and arises from the connective tissue. Its cause and pathogenesis are unknown at present. Treatment typically involves surgery, and despite apparently complete resection, local recurrences are common. We describe a case of a large angiomyxoma of the left pelvis in a 59-year-old woman who underwent two surgical excisions. The first had been done in May 1998. She developed a local recurrence in December 1998. A palliative resection with macroscopic residuals was performed in February 2001, followed by radiation therapy with a total dose of 60 Gy. The diagnosis was revised at the time of the second operation. Initially, the tumor was diagnosed as angiomyofibroblastoma. Follow-up 3 years after the radiation treatment revealed no recurrence. The time of the local control achieved as yet is already longer than the former time to progression between the first two surgical procedures. This is, to our knowledge, the second description of a therapeutic irradiation of a recurrent AAM. Radiation therapy is able to control a recurrent AAM for at least 3 years.
侵袭性血管黏液瘤（AAM）是一种罕见肿瘤，好发于盆腔和会阴区域，起源于结缔组织。其病因及发病机制目前尚不清楚。治疗通常采用手术，尽管看似完整切除，但局部复发很常见。我们报告一例59岁女性左盆腔巨大血管黏液瘤病例，该患者接受了两次手术切除。第一次手术于1998年5月进行。1998年12月出现局部复发。2001年2月进行了姑息性切除，术中可见肉眼残留，随后进行了总剂量为60 Gy的放射治疗。第二次手术时修正了诊断。最初，该肿瘤被诊断为血管肌纤维母细胞瘤。放射治疗后3年随访未发现复发。目前实现的局部控制时间已经长于前两次手术之间的疾病进展时间。据我们所知，这是复发性AAM接受放射治疗的第二篇报道。放射治疗能够控制复发性AAM至少3年。
