Keshk Eman M, Alafghani Saud O, Tariq Muhammad Usman, Kashif Ammara, Alsulaiman Abdullah
Histopathology Department, Ahmed Maher Teaching Hospital, Cairo, EGY.
Histopathology Unit, Laboratory Department, Al Hada Armed Forces Hospital, Taif, SAU.
Cureus. 2024 Dec 10;16(12):e75512. doi: 10.7759/cureus.75512. eCollection 2024 Dec.
An aggressive angiomyxoma (AA) is a rare soft tissue neoplasm of the lower female genital tract. The incidence of vaginal involvement is low, so it is commonly misdiagnosed as a Bartholin cyst, lipoma, and abscess, among others. This is a case of a 31-year-old female patient presenting with anterior vaginal wall swelling measuring 1 x 1 cm, clinically diagnosed as vaginal carbuncle. Histological and immunohistochemical examination of the lesion showed an AA. Some AAs recur locally, while distant metastasis is rare. The tumor is infiltrative with a characteristic histologic picture. The tumor is positive for high mobility group A2 (HMGA2), estrogen receptors (ERs), a cluster of differentiation 34 (CD34), and desmin immunomarkers. Due to the infiltrative nature of the tumor, surgical margins are commonly positive.
侵袭性血管黏液瘤（AA）是一种罕见的女性下生殖道软组织肿瘤。阴道受累的发生率较低，因此通常被误诊为巴氏腺囊肿、脂肪瘤和脓肿等。这是一例31岁女性患者，表现为阴道前壁有一个1×1厘米的肿物，临床诊断为阴道痈。对该病变进行组织学和免疫组化检查显示为侵袭性血管黏液瘤。一些侵袭性血管黏液瘤会局部复发，而远处转移很少见。该肿瘤具有浸润性，有特征性的组织学表现。肿瘤对高迁移率族蛋白A2（HMGA2）、雌激素受体（ERs）、分化簇34（CD34）和结蛋白免疫标志物呈阳性。由于肿瘤的浸润性，手术切缘通常为阳性。
