An Aggressive Angiomyxoma Presenting as a Vaginal Wall Carbuncle in a 31-Year-Old Female: A Case Report.

An aggressive angiomyxoma (AA) is a rare soft tissue neoplasm of the lower female genital tract. The incidence of vaginal involvement is low, so it is commonly misdiagnosed as a Bartholin cyst, lipoma, and abscess, among others. This is a case of a 31-year-old female patient presenting with anterior vaginal wall swelling measuring 1 x 1 cm, clinically diagnosed as vaginal carbuncle. Histological and immunohistochemical examination of the lesion showed an AA. Some AAs recur locally, while distant metastasis is rare. The tumor is infiltrative with a characteristic histologic picture. The tumor is positive for high mobility group A2 (HMGA2), estrogen receptors (ERs), a cluster of differentiation 34 (CD34), and desmin immunomarkers. Due to the infiltrative nature of the tumor, surgical margins are commonly positive.