Reynolds Brady, Richards Jerry B, de Wit Harriet
Columbus Children's Research Institute, Department of Pediatrics, The Ohio State University, 700 Children's Drive, J1401, Columbus, Ohio 43205, USA.
Pharmacol Biochem Behav. 2006 Feb;83(2):194-202. doi: 10.1016/j.pbb.2006.01.007. Epub 2006 Mar 3.
Alcohol is widely believed to increase impulsive behavior. However, this has been difficult to demonstrate for impulsive choice using existing measures of delay discounting. We hypothesized a new real-time discounting task would be more sensitive to acute effects of alcohol. Measures included were a (a) question-based measure of delay discounting, the (b) Experiential Discounting Task (EDT), the (c) Balloon Analogue Risk Task (BART), the (d) Stop Task, and the (e) Go/No-Go Task. A three-session, double-blind, placebo-controlled, within-subjects design was used. Placebo, 0.4, or 0.8 g/kg alcohol doses were administered in a counterbalanced order over the three testing sessions. Twenty four (13 females) healthy social drinkers between the ages of 21 and 35 participated. Alcohol increased impulsive responding only on the EDT and the Stop Task. On the EDT, participants performed more impulsively after the 0.8 g/kg dose compared to placebo, whereas on the Stop Task, both the 0.4 and 0.8 g/kg doses increased impulsive responding. Alcohol had no significant effects on the other measures. The EDT was more sensitive to the acute effects of alcohol than previously used discounting tasks. Procedural differences between the EDT and question-based measures are discussed in the context of these divergent findings.
人们普遍认为酒精会增加冲动行为。然而,使用现有的延迟折扣测量方法,很难证明酒精对冲动选择有这种影响。我们假设一项新的实时折扣任务对酒精的急性效应会更敏感。所采用的测量方法包括:(a)基于问题的延迟折扣测量方法、(b)体验式折扣任务(EDT)、(c)气球模拟风险任务(BART)、(d)停止任务和(e)Go/No-Go任务。采用了一种三阶段、双盲、安慰剂对照的受试者内设计。在三个测试阶段中,安慰剂、0.4或0.8克/千克酒精剂量以平衡的顺序给药。24名(13名女性)年龄在21至35岁之间的健康社交饮酒者参与了研究。酒精仅在EDT和停止任务上增加了冲动反应。在EDT上,与安慰剂相比,0.8克/千克剂量后参与者的行为更冲动,而在停止任务上,0.4和0.8克/千克剂量均增加了冲动反应。酒精对其他测量方法没有显著影响。与之前使用的折扣任务相比,EDT对酒精的急性效应更敏感。在这些不同的研究结果背景下,讨论了EDT与基于问题的测量方法之间的程序差异。