Gustafsson Britt, Jernberg Asa Gustafsson, Priftakis Peter, Bogdanovic Gordana
Department of Paediatrics, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
Pediatr Hematol Oncol. 2006 Apr-May;23(3):199-205. doi: 10.1080/08880010500506677.
An association of a viral infection in utero and development of acute lymphoblastic leukemia (ALL) has been suggested. Cytomegalovirus (CMV) has been reported as a leading agent of intrauterine infections resulting in some cases of congenital infections. The authors investigated the presence of prenatal CMV infection in children who later developed ALL. Guthrie cards were obtained from 48 children with ALL and 46 healthy children and were analyzed for the presence of CMV DNA by a real-time TaqMan PCR. CMV DNA was not detected in Guthrie cards from the children with ALL, from the control healthy children. The results show that prenatal CMV infection does not seem to be associated with later development of childhood ALL.
子宫内病毒感染与急性淋巴细胞白血病（ALL）的发生之间存在关联这一观点已被提出。巨细胞病毒（CMV）被报道为导致某些先天性感染的宫内感染的主要病原体。作者调查了后来患ALL的儿童中产前CMV感染的情况。从48名ALL患儿和46名健康儿童中获取了干血斑样本，并通过实时TaqMan PCR分析CMV DNA的存在情况。在ALL患儿和对照健康儿童的干血斑样本中均未检测到CMV DNA。结果表明，产前CMV感染似乎与儿童ALL的后期发病无关。
