Gustafsson B, Huang W, Bogdanovic G, Gauffin F, Nordgren A, Talekar G, Ornelles D A, Gooding L R
Department of Pediatrics, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.
Br J Cancer. 2007 Oct 8;97(7):992-4. doi: 10.1038/sj.bjc.6603983. Epub 2007 Sep 18.
Epidemiological evidence suggests that childhood acute lymphoblastic leukaemia (ALL) may be initiated by an in infection in utero. Adenovirus DNA was detected in 13 of 49 neonatal blood spots from ALL patients but only in 3 of 47 controls (P=0.012) suggesting a correlation between prenatal adenovirus infection and the development of ALL.
流行病学证据表明,儿童急性淋巴细胞白血病(ALL)可能始于子宫内感染。在49例ALL患者的新生儿血斑中,有13例检测到腺病毒DNA,而在47例对照中仅有3例检测到(P = 0.012),这表明产前腺病毒感染与ALL的发生之间存在关联。