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Br J Cancer. 2007 Oct 8;97(7):992-4. doi: 10.1038/sj.bjc.6603983. Epub 2007 Sep 18.
2
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本文引用的文献

1
Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection.单纯疱疹病毒I型在裂解感染期间破坏ATR依赖的DNA损伤反应。
J Cell Sci. 2006 Jul 1;119(Pt 13):2695-703. doi: 10.1242/jcs.02981. Epub 2006 Jun 6.
2
No CMV DNA in Guthrie cards from children who later developed ALL.后来患急性淋巴细胞白血病的儿童的古思里卡片中未检测到巨细胞病毒DNA。
Pediatr Hematol Oncol. 2006 Apr-May;23(3):199-205. doi: 10.1080/08880010500506677.
3
Infection, immune responses and the aetiology of childhood leukaemia.感染、免疫反应与儿童白血病的病因学
Nat Rev Cancer. 2006 Mar;6(3):193-203. doi: 10.1038/nrc1816.
4
The putative role of transforming viruses in childhood acute lymphoblastic leukemia.转化病毒在儿童急性淋巴细胞白血病中的假定作用。
Haematologica. 2006 Feb;91(2):240-3.
5
Inactivating intracellular antiviral responses during adenovirus infection.在腺病毒感染期间使细胞内抗病毒反应失活。
Oncogene. 2005 Nov 21;24(52):7686-96. doi: 10.1038/sj.onc.1209063.
6
Detection of viral deoxyribonucleic acid in amniotic fluid: association with fetal malformation and pregnancy abnormalities.羊水病毒脱氧核糖核酸的检测：与胎儿畸形及妊娠异常的关联
Fetal Diagn Ther. 2005 May-Jun;20(3):203-7. doi: 10.1159/000083906.
7
Diagnosis of congenital cytomegalovirus infection by detection of viral DNA in dried blood spots.通过检测干血斑中的病毒DNA诊断先天性巨细胞病毒感染
Clin Diagn Virol. 1996 Jun;6(1):27-32. doi: 10.1016/0928-0197(96)00228-0.
8
Human herpes virus 6 or Epstein-Barr virus were not detected in Guthrie cards from children who later developed leukaemia.在后来患白血病的儿童的干血斑样本中未检测到人类疱疹病毒6型或爱泼斯坦-巴尔病毒。
Br J Cancer. 2004 Aug 31;91(5):913-5. doi: 10.1038/sj.bjc.6602099.
9
Population mixing and childhood leukaemia: Fallon and other US clusters.人口混居与儿童白血病：法隆及美国其他聚集病例
Br J Cancer. 2004 Jul 5;91(1):1-3. doi: 10.1038/sj.bjc.6601982.
10
Human parvovirus B19 DNA is not detected in Guthrie cards from children who have developed acute lymphoblastic leukemia.在已患急性淋巴细胞白血病的儿童的干血滤纸片中未检测到人类细小病毒B19 DNA。
Pediatr Blood Cancer. 2004 Apr;42(4):357-60. doi: 10.1002/pbc.20001.

在患急性淋巴细胞白血病儿童的Guthrie卡片中，腺病毒DNA的检测频率增加。

Adenovirus DNA is detected at increased frequency in Guthrie cards from children who develop acute lymphoblastic leukaemia.

作者信息

Gustafsson B, Huang W, Bogdanovic G, Gauffin F, Nordgren A, Talekar G, Ornelles D A, Gooding L R

机构信息

Department of Pediatrics, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

出版信息

Br J Cancer. 2007 Oct 8;97(7):992-4. doi: 10.1038/sj.bjc.6603983. Epub 2007 Sep 18.

DOI:10.1038/sj.bjc.6603983
PMID:17876329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2360426/
Abstract

Epidemiological evidence suggests that childhood acute lymphoblastic leukaemia (ALL) may be initiated by an in infection in utero. Adenovirus DNA was detected in 13 of 49 neonatal blood spots from ALL patients but only in 3 of 47 controls (P=0.012) suggesting a correlation between prenatal adenovirus infection and the development of ALL.

摘要

流行病学证据表明，儿童急性淋巴细胞白血病（ALL）可能始于子宫内感染。在49例ALL患者的新生儿血斑中，有13例检测到腺病毒DNA，而在47例对照中仅有3例检测到（P = 0.012），这表明产前腺病毒感染与ALL的发生之间存在关联。