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肾脏中Toll样受体的表达：其在感染之外的潜在作用。

Expression of Toll-like receptors in the kidney: their potential role beyond infection.

作者信息

Schroppel B, He J C

机构信息

Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA.

出版信息

Kidney Int. 2006 Mar;69(5):785-7. doi: 10.1038/sj.ki.5000190.

DOI:10.1038/sj.ki.5000190
PMID:16518338
Abstract

Toll-like receptors (TLRs) recognize both exogenous microbial components and endogenous molecules to promote immune activation. Both immune and nonimmune renal cells express TLRs, which are involved in the pathogenesis of a number of kidney diseases, including pyelonephritis, Leptospira nephritis, immune-complex glomerulonephritis, ischemic/reperfusion injury, and rejection of kidney transplant.

摘要

Toll样受体（TLRs）可识别外源性微生物成分和内源性分子，以促进免疫激活。免疫和非免疫性肾细胞均表达TLRs，其参与多种肾脏疾病的发病机制，包括肾盂肾炎、钩端螺旋体性肾炎、免疫复合物性肾小球肾炎、缺血/再灌注损伤以及肾移植排斥反应。

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