用于多模态药物递送的碳纳米管双功能化
Double functionalization of carbon nanotubes for multimodal drug delivery.
作者信息
Pastorin Giorgia, Wu Wei, Wieckowski Sébastien, Briand Jean-Paul, Kostarelos Kostas, Prato Maurizio, Bianco Alberto
机构信息
Institut de Biologie Moléculaire et Cellulaire, UPR9021 CNRS, Immunologie et Chimie Thérapeutiques, 67084 Strasbourg, France.
出版信息
Chem Commun (Camb). 2006 Mar 21(11):1182-4. doi: 10.1039/b516309a. Epub 2006 Feb 13.
DOI:10.1039/b516309a
PMID:16518484
Abstract
Multi-walled carbon nanotubes have been covalently functionalized via 1,3-dipolar cycloaddition of azomethine ylides with orthogonally protected amino functions that can be selectively deprotected and subsequently modified with drugs and fluorescent probes.
摘要
多壁碳纳米管已通过甲亚胺叶立德与具有正交保护氨基功能的1,3-偶极环加成反应进行共价功能化，这些氨基功能可以被选择性地脱保护，随后用药物和荧光探针进行修饰。
Zotero 插件