Balmes P, Clerc G, Dupont B, Labram C, Pariente R, Poirier R
Service de Pneumologie, Centre Hospitalier Regional et Universitaire, Nimes, France.
Eur J Clin Microbiol Infect Dis. 1991 May;10(5):437-9. doi: 10.1007/BF01968024.
Forty-eight patients with acute bronchitis and four with pneumonia were randomly assigned to receive five doses (500 mg on day 1, plus 250 mg/day on days 2-5) of azithromycin; 54 patients with acute bronchitis and four with pneumonia were assigned 30 doses (625 mg every eight hours for ten days) of amoxicillin/clavulanic acid (CA). The two regimens were equally effective, with clinical improvement or cure in 92% and 87% of patients respectively, bacteriological cure in 89% and 86%, with 91% and 89% of pathogens eliminated. Minor side effects occurred in 6% and 12% of patients in the two groups, respectively. No major abnormalities in laboratory safety parameters were seen in either group.
48例急性支气管炎患者和4例肺炎患者被随机分配接受5剂（第1天500毫克，第2 - 5天每天250毫克）阿奇霉素治疗；54例急性支气管炎患者和4例肺炎患者被分配接受30剂（每8小时625毫克，共10天）阿莫西林/克拉维酸（CA）治疗。两种治疗方案疗效相当，分别有92%和87%的患者临床症状改善或治愈，细菌学治愈率分别为89%和86%，病原体清除率分别为91%和89%。两组分别有6%和12%的患者出现轻微副作用。两组均未发现实验室安全参数有重大异常。
