Mirandola Prisco, Sponzilli Ivonne, Solenghi Elvira, Micheloni Cristina, Rinaldi Laura, Gobbi Giuliana, Vitale Marco
Human Anatomy Section, Department of Anatomy, Pharmacology, and Forensic Medicine, University of Parma, Ospedale Maggiore, Parma, Italy.
J Infect Dis. 2006 Apr 1;193(7):917-26. doi: 10.1086/500561. Epub 2006 Feb 24.
Human herpesvirus (HHV)-7 is a ubiquitous virus that infects >90% of adults. We show that HHV-7 impairs beta2-microglobulin and human leukocyte antigen (HLA) class I and II expression in lymphoid cells in vitro. Accordingly, infected cells were more sensitive to peripheral blood natural cytotoxic activity than were uninfected cells. Analysis of beta2-microglobulin and HLA expression in biopsy specimens from human submandibular glands confirmed the ability of HHV-7 to modulate the expression of these antigens in vivo. We demonstrate that the down-modulation of HLA by HHV-7 is linked to viral replication and is not merely a consequence of the interaction of virions with the cell surface. Infected cells can therefore efficiently escape host immune pressure, which might explain the persistence of HHV-7-positive cells in several kinds of tumors and chronic infectious diseases.
人类疱疹病毒7型（HHV-7）是一种普遍存在的病毒，感染超过90%的成年人。我们发现，HHV-7在体外可损害淋巴样细胞中的β2微球蛋白以及人类白细胞抗原（HLA）I类和II类的表达。因此，与未感染细胞相比，感染细胞对外周血自然细胞毒性活性更敏感。对人类下颌下腺活检标本中β2微球蛋白和HLA表达的分析证实，HHV-7在体内具有调节这些抗原表达的能力。我们证明，HHV-7对HLA的下调与病毒复制有关，而不仅仅是病毒粒子与细胞表面相互作用的结果。因此，感染细胞能够有效地逃避宿主免疫压力，这可能解释了HHV-7阳性细胞在几种肿瘤和慢性传染病中的持续存在。
