Institute of Microbiology and Virology, Rīga Stradiņš University, Riga, Latvia.
Biocenter, Chair of Microbiology, University of Würzburg, Würzburg, Germany.
J Transl Med. 2018 Oct 1;16(1):268. doi: 10.1186/s12967-018-1644-y.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and controversial clinical condition without having established causative factors. Increasing numbers of cases during past decade have created awareness among patients as well as healthcare professionals. Chronic viral infection as a cause of ME/CFS has long been debated. However, lack of large studies involving well-designed patient groups and validated experimental set ups have hindered our knowledge about this disease. Moreover, recent developments regarding molecular mechanism of pathogenesis of various infectious agents cast doubts over validity of several of the past studies.
This review aims to compile all the studies done so far to investigate various viral agents that could be associated with ME/CFS. Furthermore, we suggest strategies to better design future studies on the role of viral infections in ME/CFS.
肌痛性脑脊髓炎/慢性疲劳综合征（ME/CFS）是一种复杂且有争议的临床病症，其病因尚未确定。过去十年中，病例数量不断增加，使患者和医疗保健专业人员都提高了认识。慢性病毒感染一直是 ME/CFS 的一个潜在病因，但由于缺乏涉及设计良好的患者群体和经过验证的实验设置的大型研究，我们对这种疾病的了解仍受到阻碍。此外，最近关于各种感染性病原体发病机制的分子机制的发展，对过去的一些研究的有效性提出了质疑。
本综述旨在汇集迄今为止针对可能与 ME/CFS 相关的各种病毒因子所做的所有研究。此外，我们还提出了策略，以更好地设计未来关于病毒感染在 ME/CFS 中的作用的研究。
