Thompson Sarah K, Chang Eugene Y, Jobe Blair A
Department of Surgery, Oregon Health and Science University, Portland, OR, USA.
Microsurgery. 2006;26(3):131-6. doi: 10.1002/micr.20197.
Gastrointestinal healing is a topic rarely reviewed in the literature, yet it is of paramount importance to the surgeon. Failure of anastomotic healing may lead to life-threatening complications, additional surgical procedures, increased length of stay, increased cost, long-term disability, and reduced quality of life for the patient. The goal of this article is to review the biological response to wounded tissue, to outline discrete differences between skin and gastrointestinal healing, to discuss local and systemic factors important to gastrointestinal healing, and to compare methods of measuring collagen content and strength of the newly formed anastomosis. Part II of this review will focus on techniques and therapies available to optimize anastomotic healing.
胃肠道愈合是文献中很少被综述的一个话题，但对外科医生来说却至关重要。吻合口愈合失败可能导致危及生命的并发症、额外的手术、住院时间延长、费用增加、长期残疾以及患者生活质量下降。本文的目的是综述对受伤组织的生物学反应，概述皮肤和胃肠道愈合之间的明显差异，讨论对胃肠道愈合重要的局部和全身因素，并比较测量新形成吻合口的胶原蛋白含量和强度的方法。本综述的第二部分将重点介绍可用于优化吻合口愈合的技术和疗法。
