Marjanovic G, Hopt U T
Abteilung für Allgemein- und Viszeralchirurgie, Albert-Ludwigs-Universität, Freiburg, Deutschland.
Chirurg. 2011 Jan;82(1):41-7. doi: 10.1007/s00104-010-1898-2.
Anastomotic insufficiency still remains the most dreaded complication following digestive surgery. The surgeon's understanding of the mechanisms underlying anastomotic healing and the possible weak points are just as important as a correct anastomotic technique. Intestinal anastomotic healing is a complex, cell-mediated process which aims at restoring bowel wall continuity. The early stages of anastomotic healing are most susceptible to various sources of irritation, which is reflected by the likelihood of early anastomotic insufficiency. In our opinion, the focus of future research should shift from primarily examining pathogenetic factors to a more cellular and molecular level. A better comprehension of the anastomotic healing process might thus promote the development of new diagnostic predictive and therapeutic methods.
吻合口漏仍然是消化系统手术后最可怕的并发症。外科医生对吻合口愈合的潜在机制以及可能的薄弱点的理解与正确的吻合技术同样重要。肠吻合口愈合是一个复杂的细胞介导过程，旨在恢复肠壁的连续性。吻合口愈合的早期阶段最易受到各种刺激源的影响，这反映在早期吻合口漏的可能性上。我们认为，未来的研究重点应从主要检查发病因素转向更细胞和分子水平。因此，更好地理解吻合口愈合过程可能会促进新的诊断预测和治疗方法的发展。
