Sutthiruangwong Piriya, Thanakit Voranuch, Assavamongkolkul Apichat
Department of Pathology, Chonburi Hospital, Chonburi 2000, Thailand.
J Med Assoc Thai. 2005 Oct;88(10):1453-7.
Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor with low-grade malignancy which occurs chiefly in children and young adults. Mostly, the tumor develops in the extremities or the trunk. The tumor has a relatively rare metastasis and its overall clinical outcome is excellent. The authors present a case of AFH of the subcutis on a left elbow of an 11-year-old boy. Clinically, the tumor appears as a cutaneous nodule with slow growth. Pain and adjacent lymphadenopathy are leading symptoms of the patient. Histological examination shows the classical morphological features of AFH with focal cellular atypia. The tumor has immunoreactivity to vimentin and CD68 but negative to CD34, desmin, CD117 and S-100 protein. Because of its rarity, we report a case with an uncommon clinical presentation in a Thai patient.
血管样纤维组织细胞瘤（AFH）是一种罕见的低度恶性软组织肿瘤，主要发生于儿童和青年。多数情况下，肿瘤发生于四肢或躯干。该肿瘤转移相对少见，总体临床预后良好。作者报告了一例11岁男孩左肘部皮下AFH病例。临床上，肿瘤表现为生长缓慢的皮肤结节。疼痛和邻近淋巴结病是该患者的主要症状。组织学检查显示AFH的典型形态特征，伴有局灶性细胞异型性。肿瘤对波形蛋白和CD68呈免疫反应性，但对CD34、结蛋白、CD117和S-100蛋白呈阴性。由于其罕见性，我们报告了一例泰国患者临床表现不常见的病例。
