Lee P A, Xenakis T, Winer J, Matsenbaugh S
J Clin Endocrinol Metab. 1976 Oct;43(4):775-84. doi: 10.1210/jcem-43-4-775.
Twenty-seven girls aged 8 to 18 were studied in a longitudinal prospective fashion. Serum samples were collected at 6 month intervals up to 4 years and radioassayed for hormones of pituitary, ovarian, and adrenal origin. A progressive elevation of luteinizing hormone (LH), follicle-stimulating hormone/FSH), estradiol (E2), dehydroepiandrosterone (DHA), and androstenedione (delta4) occurred during puberty and continued until menarche. The onset of puberty occurred concomitantly with an elevation of estrone (E1) dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DHAS), and 17-hydroxyprogesterone (17-OH-P). Prolactin (Prol) and progesterone (Prog) concentrations did not change during puberty until after menarche. After menarche, levels of LH and FSH were comparable with menstruating adult females. Concentrations of E2 and Prog were lower during the second half of the cycle among most regularly menstruating subjects than expected during the luteal phase. LH and Prog levels indirectly suggest that ovulation occurs in a few girls within months after menarche.
对27名年龄在8至18岁的女孩进行了纵向前瞻性研究。每隔6个月采集一次血清样本，持续4年，并对垂体、卵巢和肾上腺来源的激素进行放射分析。青春期期间促黄体生成素（LH）、促卵泡生成素（FSH）、雌二醇（E2）、脱氢表雄酮（DHA）和雄烯二酮（δ4）逐渐升高，并持续至初潮。青春期开始时，雌酮（E1）、脱氢表雄酮（DHA）、硫酸脱氢表雄酮（DHAS）和17-羟孕酮（17-OH-P）也随之升高。青春期期间，催乳素（Prol）和孕酮（Prog）浓度在初潮前没有变化。初潮后，LH和FSH水平与成年女性月经周期时相当。在大多数月经规律的受试者中，周期后半期E2和Prog的浓度低于黄体期预期水平。LH和Prog水平间接表明，初潮后数月内少数女孩会发生排卵。
