Rozyńska Renata, Jahnz-Rózyk Karina, Targowski Tomasz, Grabowska Patrycja, From Sławomir
Klinika Chorób Wewnetrznych Pneumonologii i Alergologii Centralnego Szpitala Klinicznego Ministerstwa Obrony Narodowej Wojskowy Instytut Medyczny, Warszawa.
Przegl Lek. 2005;62(10):1047-50.
The aim of the study was to assess the influence of smoking on the metalloproteinase 1 (MMP-1) concentration in serum in the group of patients with chronic obstructive pulmonary disease (COPD). The study comprised 26 patients with COPD. The control group was created of 15 healthy non-smoking subjects. In the both group spirometry test was performed. The concentration of MMP-1, C-reactive protein, OB level was estimated in serum. Significant differences were noticed in the MMP-1 concentration in serum between groups (p=0.013). Significantly higher OB level (p=0.011) and C-reactive protein concentration (p=0.03) was found in the COPD group. In this same group positive correlation between MMP-1 concentration in serum and the packyears was noticed (r=0.50). No significant correlation was found between inflammatory indicators and the number of packyears. No significant correlation was noticed between MMP-1 level and FEV1 in COPD group. The analysis of the data shows significant influence of smoking on the increase of MMP-1 concentration in serum in the group of COPD patients.
该研究的目的是评估吸烟对慢性阻塞性肺疾病（COPD）患者血清中金属蛋白酶1（MMP-1）浓度的影响。该研究纳入了26例COPD患者。对照组由15名健康非吸烟受试者组成。两组均进行了肺功能测试。测定了血清中MMP-1、C反应蛋白、OB水平。两组间血清MMP-1浓度存在显著差异（p=0.013）。COPD组的OB水平（p=0.011）和C反应蛋白浓度（p=0.03）显著更高。在同一组中，血清MMP-1浓度与吸烟包年数之间存在正相关（r=0.50）。炎症指标与吸烟包年数之间未发现显著相关性。COPD组中MMP-1水平与第一秒用力呼气容积（FEV1）之间未发现显著相关性。数据分析表明，吸烟对COPD患者血清中MMP-1浓度的升高有显著影响。
